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Glutathione recycling helps balance immune function and shield thyroid tissue from inflammation and autoimmune attacks

Oncoimmunology 9 , 1809947 (2020)

It plays a central role in tissue regeneration, wound healing, collagen synthesis, and anti-aging processes , and is naturally present in human plasma and extracellular matrix

Agnihotri S, Kaur J, Masand P, Parihar VK, Sharma A (2023) Vitamins strategies for psoriasis: an update on current scientific evidence

Feb;12(4):711

In addition to its role in UPR-driven transcriptional changes via XBP1 splicing, IRE1 is involved in the regulated IRE1-dependent mRNA decay (RIDD) to halt further translation, thereby inhibiting excessive protein burden in the ER and ensuring proteostasis under conditions of ER stress