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GH is likely to be involved in the above process simply by its ability to upregulate local IGF production through classical JAK/STAT signaling, but JAK2 can also directly cross phosphorylate IRS1/2 adding another link to the GH-GHR cascade (118, 119)

As a result, they should not be considered interchangeable compounds

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Rather than flooding synapses with a single neurotransmitter, it modulates the balance between serotonin, dopamine, and norepinephrine, nudging each toward optimal levels rather than artificially elevating one at the expense of others

Lukaszewicz, A., Savatier, P., Cortay, V., Kennedy, H