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6 Vmes neurons as therapeutic targets The Vmes consists of primary afferent neurons that transmit proprioceptive information from the masticatory muscles to the brainstem, playing a crucial role in the control of mastication

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Haynes et al., 1997), thus causing an increase in energy expenditure (Woods and Stock, 1996) and in sympathetic vasomotor activity (Marsh et al., 2003)

Proteomics 2013

The intermittent pattern lets BDNF signaling cycle naturally without provoking compensatory downregulation