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Circulating GLP-1 exists only at low picomolar concentrations, is rapidly inactivated by DPP-4 enzymes and is swiftly cleared by the kidneys (Hansen et al., 1999

PMC 1636736

As a modified version of the naturally occurring GLP-1 hormone, semaglutide has a 94% amino acid sequence homology to human GLP-1 but includes strategic modifications that extend its half-life to approximately one week, enabling once-weekly dosing

23 Preclinical studies have demonstrated that liraglutide stimulates IL-10 secretion, an anti-inflammatory cytokine, thereby alleviating migraine-like pain in rats

Gough SCL, Bode B, Woo V, et al