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When used alone, the inhibition of 5-LOX by Zileuton led to the accumulation of AA

Indirect markers include elevated oxidative stress markers, poor recovery from exercise, chronic fatigue, weakened immune function, or elevated liver enzymes

Pruritus, a common and distressing symptom, is managed with moisturizers, antihistamines, and other medications like cholestyramine, though many treatments have limited efficacy

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Stress management: Since emotional stress can be a trigger, stress management techniques can be a helpful part of a comprehensive management plan [3]