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SIRT1, an NAD + -dependent class III histone deacetylase, regulates hepatic lipid metabolism through deacetylation of multiple transcription factors and metabolic enzymes, exerting a bidirectional effect on lipid homeostasis by inhibiting fat synthesis and promoting fatty acid oxidation

PMID 20306513

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They make it easier for the body to break down and eliminate those stubborn, unwanted fat stores

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(2019) found that epithalon therapy normalized circadian gene expression in peripheral tissues, leading to improved sleep-wake cycles and enhanced sleep quality scores