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Am J Physiol-Reg I

Tirzepatide and sermorelin operate through fundamentally different physiological pathways, making their mechanisms of action distinct yet potentially complementary in metabolic management

The second group (liraglutide, dulaglutide and semaglutide) have a modified human GLP-1 structure and, hence, a much closer homology to that of GLP-1 itself

A good example of this is growth hormone secretagogues peptides that facilitate growth hormone secretion whose capacity to promote physical growth can trigger the growth and spread of tumors.18 For that reason, peptides such as sermorelin, tesamorelin, and CJC-1295 are contraindicated for people with active cancer, as well as those with a personal or familial history of cancer

Journal of Neurochemistry 74:457471

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