Furthermore, adipose tissue biology undoubtedly changes before the mass of adipose tissue is measurably reduced, and this may in part mediate the earliest effects of semaglutide on MACE. The temporal dissociation between weight loss and MACE reduction observed in our study supports the hypothesis that these and other mechanisms may play a key role in vascular protection, the authors add
10.1016/j.tibs.2020.11.007 Trends Biochem
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Compared with other antidiabetic or weight-reducing treatments, GLP-1 receptor agonists produced increased gonadotropins and sex hormone-binding globulin and improved erectile function, with serum androgen levels comparable to or exceeding those of other agents
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