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The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise

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You may experience redness, swelling, or a mild tenderness

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The depletion of glutathione (an antioxidant needed to remove the cyanide from cyano B12) may increase homocysteine, thus only making things worse for these patients