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Recent genomic and transcriptomic profiling of tumors of patients with GBM following treatment with PD-1 inhibitors nivolumab or pembrolizumab revealed a significant enrichment of PTEN mutations associated with immunosuppressive expression signatures in non-responders [107]

Observations Spinal MMNSTs arise from neural crestderived Schwann cells with aberrant melanocytic differentiation, and genetic studies have identified mutations associated with this disease

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