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This may involve a key are of the brain reward circuit, the ventral striatum, with experimenters showing if they directly administer GLP-1 agonists into this region, rats show reduced craving for oxycodone or cocaine, possibly through reducing drug-induced dopamine release

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In select cases, we may sequence or combine GLP-1/GIP agonists under close supervision

It has an elimination half-life of around 5 days, allowing for once-weekly dosing

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Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome