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Moving forward, the redox status and activity of BiP will be of particular interest, given its roles in protein folding, ERAD, protein translocation, and UPR signaling (Pobre, Poet, & Hendershot, 2019), and the fact that oxidative modifications can alter the nature of its associations with nascent proteins (J

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Insert the needle at a 45-90 degree angle (90 degrees is typical for insulin syringes with short needles)

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Therefore, the present finding of high expression of Nrf2 along with high SIRT1 expression in ovarian cells indirectly confirms the regulatory role of SIRT1 in protecting the GCs against ROS

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