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First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid tumors and lymphomas

Starting conservatively and adjusting based on observed effects represents the most prudent approach given limited clinical guidance

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Compounds that disrupt glucose-insulin dynamics typically create hunger patterns that interfere with dietary adherence

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