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Curcumin also downregulates vascular endothelial growth factor (VEGF), a protein produced by cells that stimulates the formation of blood vessels ( 12 )

In NUC consolidation group, patients received (quartile [Q]1, Q3, 23.00, 96.00) weeks oral NUCs therapy

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Arterioscler Thromb Vasc Biol 15 : 13141320

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Once the hepatotoxicity due to APAP was recognized, the mechanisms behind this were extensively investigated, especially in the mouse model, which recapitulates key mechanistic aspects of liver injury in humans such as mitochondrial dysfunction [5,6]