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While three studies found no differences in glutathione reductase activity in the airway lavage cells (300), epithelial lining fluid (88), and erythrocytes (254) of asthmatics versus healthy controls, others have observed decreased glutathione reductase activity in erythrocytes from asymptomatic asthmatics as compared to controls (124, 208)

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In such cases, the focus should shift to investigating potential underlying causessuch as myeloproliferative disorders, liver disease, or renal dysfunctionrather than attributing symptoms to the elevated B12 itself

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