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In patients with T2D being overweight or obese, tirzepatide treatment resulted in significant body weight reductions (6976)

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20 Its target, thyroid hormone receptor beta, is predominantly expressed in the liver: apparently, even people with normal thyroid hormone levels systemically can have intrahepatic hypothyroidism, leading to hepatic steatosis and inflammation, which this drug can counteract

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Nevertheless, ClinicalTrials.gov