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Unlike other Na + -dependent MFS transporters, such as MelB 37 and MFSD2A 38,39,40 , where the Na + site forms part of the substrate-binding cavity, the OCTN2 Na + -binding site is buried within a solvent-filled cavity in the N-terminal bundle

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31 Likewise, GLP-1 was suggested as a potential risk indicator of metabolic syndrome in a recent study in adults

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Safety data Of the participants, 75% in both orforglipron groups, 71% receiving semaglutide 7 mg and 72% receiving semaglutide 14 mg experienced an adverse event