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TRIUMPH-4 is the first pivotal trial to confirm that the weight-loss signal seen in Phase 2 scales with longer exposure and higher doses, and it adds several new secondary findings that reshape how researchers think about 9 mg and 12 mg as working doses

Tagliabue M, Pinach S, Di Bisceglie C, et al Glutathione levels in patients with erectile dysfunction, with or without diabetes mellitus Int J Androl

The GnRH receptor is also found in certain cancers, and the reduction in circulating estrogen slows the growth of hormone receptor-positive tumors such as ovarian cancer 117 , prostate cancer 118 , and breast cancer 119,120,121

Vaquero, A., Sternglanz, R

This is where careful readers need to slow down

Paired-end sequencing reads in a pool were demultiplexed on the basis of their associated barcode sequence using custom scripts ( Reads were then trimmed using cutadapt v1.6 and trimmed reads were aligned to the Mus musculus mm10 genome using tophat2 v2.0.11 and bowtie2 v2.2.2