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Furthermore, the expression of COX-2 and 5-lipoxygenase (5-LOX) was enhanced in the brain tissue cells and blood vessels of C57BL/6 mice and CBA mice

Cancer Immunol Immunother 73(5):85, 2024

The Ha locus comprises three genes (46), encoding proteins called puroindoline a (Pin a), puroindoline b (Pin b) and grain softness protein (GSP)

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One proposed mechanism of action is that stimulation of 5-HT 2C receptors in pro-opiomelanocortin (POMC) neurons within the arcuate nucleus of the hypothalamus leads to increased release of -MSH (Garfield and Heisler, 2009)