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One article proposed that excessive serotonin levels could explain classic symptoms of ME/CFS (433), as it would promote the release of excess CRH, and therefore cause chronic reactivation of the HPA axis (434)

Renal impairment, elevated vascular resistance and stiffness, and structural cardiac disorders like left ventricular hypertrophy and stroke are all brought on by the adverse effects of hypertension on the bodys normal functioning (24)

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Only by understanding completely the mechanisms and impact of estradiol action on the developing brain can we also understand when these processes go awry