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Mandatory G6PD screening is critical because individuals with this deficiency can experience rapid red blood cell breakdown (hemolysis) when given high-dose IV vitamin C, leading to serious health complications

This requires demonstration of safety and efficacy

For intestinal gas, the dosage could range from 500 to 1,000mg a day

In data analysis, the elimination half-life of cagrilintide was found to be 78 days, with maximum exposure 2425 hours after administration, making it suitable for once-weekly dosing

Southeast Asian J Trop Med Public Health 45(1):187193 Phompradit P, Kuesap J, Chaijaroenkul W, Rueangweerayut R, Hongkaew Y, Yamnuan R et al (2011) Prevalence and distribution of glucose-6-phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand