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Aug 2019;32(4):581-587

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Bardoxolone methyl: drug development for diabetic kidney disease

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Enzymes involved in Phase II metabolism include sulfotransferase (SULF), acetyltransferase (ACT), uridine 5-diphosphoglucuronosyl transferase (UGT), catechol-O-methyltransferase (COMT), which catalyze reactions giving rise to the corresponding sulfated, glucuronic, methylated, and acetylated HTyr derivatives, as depicted in Scheme 2 [86,87,88]

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