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In animal models, researchers measure parameters such as circulating free fatty acids, respiratory exchange ratios, and adipose tissue gene expression to characterize shifts in substrate utilization

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The active ingredient is the same molecule, but manufacturing standards, quality assurance processes, and batch testing protocols differ

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We removed the cost per response measurement from our total cost calculations and, instead, determined cost as a function of hourly wage rates per labor category identified in Tables D-A1 and D-A2 of this final rule multiplied by the annual hours per labor category

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