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The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize

What this tells us is that LASSS does more than simply neutralize reactive molecules

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Practical Implications of No IGF-1 Elevation: The absence of IGF-1 stimulation makes AOD-9604 suitable for populations who need to avoid IGF-1 elevation, including individuals with personal or family history of hormone-sensitive cancers, those concerned about accelerated aging through growth pathway activation, people seeking fat loss without anabolic muscle-building effects, individuals who have contraindications to growth hormone therapy, and those undergoing screening or monitoring where IGF-1 elevation would be problematic