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395 The loss of double-strand repair pathway due to BRCA1 or BRCA2 mutations renders cancer cells more dependent on the PARPs-mediated repair, and more sensitive to PARP inhibition, raising a possibility of a wider application of PARPi in cancer therapy
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10.1186/s12933-016-0468-4 9
Upregulation of E 2 can cause endometriosis or PCOS, while melatonin decreases levels of Ein ovaries and ER in uterine tissue by suppressing E 2 production through MAPKs
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