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Extensive anaerobic subculturing of human feces identified no single commensal capable of l-carnitineTMA transformation, multiple community members that converted l-carnitine to BB, and only 1 Clostridiales bacterium, Emergencia timonensis , that converted BB to TMA

In addition, Guo et al

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More broadly: Employer coverage is scaling fast: 64% of Americas largest employers now cover weight-loss drugs, up from 56% a year ago (source) PBMs are locking in controls: CVS Caremark, Express Scripts, Optum Rx, and Prime are adding GLP1s to formularies with step edits, prior auths, and exclusions (source) Were at a real infection point

Since then, the mechanisms and benefits of GLP-1s have become better understood and revealed new opportunities where they could potentially be used in the treatment of additional conditions

Patients on tirzepatide were almost three times more likely to achieve significant weight loss than those on semaglutide