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Olesoxime delays muscle denervation, astrogliosis, microglial activation and motoneuron death in an ALS mouse model

2.3 Anthraquinones Rhein, an anthraquinone derivative of Rheum palmatum L

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The three common variants 2, 3, and 4 differ structurally by the presence of cysteine or arginine at two key positions: * APOE 2/2 Cysteine/Cysteine * APOE 3/3 Cysteine + Arginine * APOE 4/4 Arginine/Arginine The structural shift from cysteine to arginine alters the proteins shape and function

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That overlap is part of why this combination gets discussed so often here