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51 Ravera et al studied the concentration-dependent metabolic effect of metformin and reported that low concentration (15150 M), which represents the clinical levels of the drug triggered oxidative phosphorylation, the oxidative stress response, and the AMPK/Sirt1 pathway, whereas 1.5 mM was hazardous

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These epidemiological trends have accelerated the development of pharmacological strategies capable of inducing sustained weight reduction

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