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The old erythrocytes also increase in density as they bind to autologous IgG (immunoglobulin G), that serves as an initiator for the removal of senescent erythrocytes

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Therefore, the positive cardiovascular effects of GLP-1RAs might be partially attributed to their ability to protect the kidneys, potentially restoring communication between the gut and kidneys

After reading the full-text articles, 75 more were further excluded (Supplemental Table-S2)

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Update 15 , 613622 (2009)