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Because it can help thin and loosen mucus while also influencing oxidative stress and inflammation, it has been studied extensively in chronic bronchitis and COPD.1 12 A 2015 meta-analysis found that NAC reduced exacerbations in people with chronic bronchitis and COPD, though more recent research suggests benefits may vary depending on the patient population and dose used.1 22 Women with PCOS or insulin-resistance concerns NAC has become one of the more widely studied supplements for PCOS

That doesnt mean its wrong the chemistry is reasonable but it does mean the 100x more potent claims you see in promotional copy are essentially marketing language layered on top of plausible but unverified pharmacokinetic logic

This is critical data to have before seeking FDA approval

You are advised to check labels

In people whose B12 is already in the normal range, the data is more modest

Nature 409 , 729733 (2001)