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A burning or sharp pain during injection (this may indicate you've hit a blood vessel or muscle) Medication leaking out of the injection site Injection site reactions like bruising, swelling or redness that worsen after the injection Shortness of breath call 911 if this occurs The medication isn't having its intended effects, such as reduced appetite

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Obesity also downregulates expression of adiponectin, which promotes insulin sensitivity under healthy conditions (Kawai 2021)

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