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Some individuals may experience increased heart rate, though this is typically small and of limited clinical relevance

The clinical significance is generally modest, but caution is warranted for medicines with a narrow therapeutic index

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The creation of microthrombi inside the microcirculation can also hinder blood flow, while increasing blood viscosity (thickness) can impede blood flow via these smaller capillaries (Miranda et al., 2016)

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A p-value 0.05 was considered statistically significant