10.1016/j.pain.2011.06.017 49 JiX
Beyond POTS, autonomic dysfunction in long COVID can present as: Dysregulated sweating Impaired gastrointestinal muscle contractions, causing constipation, pain, nausea, or weight loss Temperature dysregulation An exaggerated fight-or-flight response The vagus nerve within this systemthe primary parasympathetic nerve connecting the brain to the gut, heart, and lungsappears to be particularly vulnerable to COVID-19-related damage, with implications for heart rate variability, gut function, and the inflammatory regulatory role the vagus nerve normally performs
They are metabolically active, producing a host of hormones and enzymes
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Interference with Cellular Repair: These drugs may prevent nerves from repairing themselves effectively
From a pharmacological perspective , Wegovy and HRT work through entirely different mechanisms and target different physiological systems
