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In summary, clarifying the link between the gut-joint axis and ferroptosis in OA would be of great significance not only for better understanding the pathological processes at multi-levels (local joint tissues, the gut environment, and circulation), but also from a unique angle for guiding novel therapies development in OA Deep investigative approach to understand how major gut bacterial metabolites (tryptophan-derived metabolites, TMAO and so on) modulate ferroptosis in OA is very promising to elucidate the central regulatory mechanism acted by the gut-joint axis on ferroptosis in OA

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Adv Mater (2022) 34(37):2202625

The regenerative powers of AOD have also been noted to help individuals who suffer from conditions like osteoarthritis and osteoporosis

doi: 10.1371/journal.ppat.1000561 145 LiTHuangXYuanZWangLChenMSuFet al

Activation of Tissue Remodeling Proteases GHK-Cu activates matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in a balanced way that facilitates controlled extracellular matrix remodeling breaking down damaged collagen and replacing it with new, organized fibrillar collagen rather than scar tissue