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Kurt et al found that DM-associated ED patients have lower flow-mediated dilation, higher ET-1 levels, and elevated ischemia-modified albumin (an early ischemic marker) compared to non-DM-associated ED subjects [77]

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This is further supported by scRNA-seq results from our study, which show that many DEGs associated with immunity, cellular senescence, degenerative disease, or inflammation were significantly upregulated or downregulated in the model group but restored toward baseline in the WCV-treated group