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Potential Effects of Tirzepatide on Infants While there is no direct evidence on how tirzepatide might affect a nursing baby, it is important to consider the drugs mechanism of action

Mt Sinai J Med 55: 1120

doi:10.1590/S0042-96861999000900007 (archival DOI reference) Hope J

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It is important to note that the upregulation of IL-33 observed in some GLP-1 studies does not universally guarantee mucosal defense, as IL-33 can also drive potent Th2 inflammatory responses depending on the tissue context (53)

GLP-1 receptor agonists were initially developed to improve glycemic control in type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, with additional effects on appetite regulation and gastric emptying later recognized as clinically relevant (Chao et al