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Knockout of the GIP receptor blocks LTP potentiation in the CA1 area of the hippocampus and induces synaptic dysfunction in mice [105]

Key Takeaways Tesamorelin is FDA-approved and targets visceral abdominal fat through a precise growth hormone-releasing mechanism, making it the first choice for patients focused on body composition and fat reduction

Commonly available GLP-1 RAs include exenatide, liraglutide, dulaglutide, and semaglutide (injectable and oral) 7

Brain Behav Immun 2015, 45: 297310

Do not inject into a vein or muscle Change (rotate) your injection site within the area you choose with each injection to reduce your risk of getting lumps under the skin (cutaneous amyloidosis)

Unlike the more receptor-selective MT-1 (Afamelanotide), Melanotan II engages the full breadth of this system, binding MC1R, MC3R, MC4R, and MC5R, making it the compound of choice for researchers who need to study the integrated behaviour of the melanocortin network rather than a single receptor subtype in isolation