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113,114 Substrates recruited by Yos9 and Hrd3 are delivered to a complex containing Hrd1 and Der1, where the substrate associates with a groove in Hrd3 and a Yos9 lectin domain (on its luminal side) while its loop is inserted into the ER membrane

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This article is based on research published in Alternative Therapies in Health and Medicine (2021) by Edwin Lee and Blake Padgett

De Crescenzo F, DAl GL, Morgano GP, Minozzi S, Mitrova Z, Saulle R, et al