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ABT263 (navitoclax), a Bcl-xL/Bcl2/Bcl-w inhibitor, was initially screened as a senolytic agent that could be used to eliminate senescent HSCs and hMSCs

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Tissue preparation and immunohistochemistry Tumors from mice treated with placebo, E 2 , BSO, or BSO plus E 2 were excised and fixed in 10% formalin, embedded in paraffin wax blocks and sectioned

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