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For this reason, host-directed therapies have emerged in recent years as an attractive and novel strategy to tackle malaria infections ( Plasmodium liver stages ( Erythrocytes display a form of programmed cell death distinct from senescence termed eryptosis ( Plasmodium parasites, and most of the compounds tested were reported to affect parasite viability in vitro and in murine models (reviewed in in vivo , and few of those tested in vitro , induced PS exposure of uninfected erythrocytes (reviewed in Plasmodium growth ( Plasmodium in vitro cultures are conducted in RPMI 1640 media complemented with Albumax (a serum replacement) at 4% hematocrit ( Plasmodium cultures has been hypothesized to contribute to the absence of PS exposure induction, through sequestration of the eryptosis-inducing compound ( Plasmodium growth
