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6 Ms all del ABCDE, consulta a un mdico si la mancha sangra sin razn aparente , si va acompaada de cambios en la textura del tejido (costra, induracin, lcera que no cierra), o si apareci de forma muy rpida sin causa identificable

Data analysed by two-way repeated measures ANOVA to assess main effect effects of treatment ( b , c , f , g , j , k and m ) and two-way ANOVA, multiple comparison, Bonferroni post hoc test ( h )

doi: 10.1038/s41430-020-0564-0

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