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J Vet Pharmacol Therap
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463,464 In addition, a recent study demonstrated that the activation of the NLRP3 inflammasome induced by Na + is dependent on ENaC and IsoLG(isolevuglandins), and this was an important mechanism in the pathogenesis of sensitive hypertension
ZXGD regulated lipid metabolism to reduce cell lipid toxicity in rats with PH To further elucidate modulatory mechanism of ZXGD on lipid metabolism dysregulation involved in pulmonary vascular remodeling, firstly, we tested the levels of TC, LDL-C, and HDL-C in serum, additionally, we investigated the expression of key proteins involved in lipid metabolism, including peroxisome proliferator-activated receptor gamma (PPAR), phospholipase A2 (PLA2), and the marker protein for lipid droplets perilipin 2 (PLIN2), furthermore, we assessed lipid metabolite decadienyl-l-carnitine (C10:2) in lung tissues, lastly, we analyzed lipid droplets in PASMCs using oil red O staining
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