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seek urgent care for severe abdominal pain or signs of dehydration

Many patients are now asking what comes next after GLP-1 and dual agonist therapies plateau

Those who regained more saw those benefits erode significantly

Primary risks include additive cardiovascular effects (increased heart rate and blood pressure), intensified gastrointestinal symptoms (nausea, vomiting, diarrhea), and potential for serious adverse events including pancreatitis and acute kidney injury requiring close monitoring

patients should be advised to use a non-oral contraceptive method or add a barrier method for 4 weeks after initiation and each dose increase