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Human clinical data remains limited
10.1007/s00281-015-0529-x 386
liver glucose production decreases22 and intestinal glucose uptake increases, acting as a hyperglycemia clearance mechanism in diabetes.23 The effect of metformin on body weight is neutral, though in some cases it induces modest weight loss.24 While it is a safe drug, its gastrointestinal side effects appear to be underestimated in the literature.4 Gradual dose titration and administration with food is advised in order to improve tolerance of this drug
The past several decades have been boom times for innovation across multiple CVD risk factors, bringing forth an abundance of medications to regulate lipids, control blood pressure, lower blood sugar and improve inflammation
Side effects may include nausea, vomiting, abdominal pain, and diarrhea
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