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Only one study in 24 individuals, the majority of which were healthy, reported that DSIP can reduce the depth of anesthesia, increase heart rate and even reduce the intensity of delta-waves in these subjects [28]

Dos Santos EF, Busanello ENB, Miglioranza A, Z, Barchak AG, Vargas CR, et al

Some nootropics may enhance learning, memory, and information recall over time

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And, of course, people with estrogen receptor-positive breast cancer tend to get estrogen blocking drugs like tamoxifen so Im not sure if the marginal contribution of a little less estrogen from fat makes a biological difference here