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The Dual Agonist Advantage: GLP-1 and GIP Unlike earlier medications that targeted only one pathway, tirzepatide is a novel dual agonist, mimicking the action of two naturally occurring incretin hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

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Dehydration and electrolyte imbalance represent an important consideration

Further support for the involvement of iron in pathogenesis is provided by the recent discovery of a new form of cell death, ferroptosis

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Weight regain is a possibility with both medications when treatment ends, which is why obesity is increasingly treated as a chronic condition that benefits from long-term, supervised care