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A GIP agonist, ZP6590 (Zealand Pharma) is currently in a phase 1 trial, and a GLP-1/GIP antagonist, maridebart cafraglutide (formerly AMG 133, Amgen) is currently in phase 2 trials

Under formal rules, Medicare is legally prohibited from covering weight loss medications

These structural differences between semaglutide and tirzepatide obviously have consequences for their biological actions

By treating obesity, if we're impacting obesity and potentially 200 obesity-related diseases and complications, these medicines will save millions of lives." Like any drug, GLP-1s could have side effects, the most common being gastrointestinal distress

A study published in 2023 in the medical journal JAMA found that people who take these medications may be at an increased risk for pancreatitis (inflammation of the pancreas) and gastroparesis, sometimes called stomach paralysis because the stomach cant empty

some patients achieve excellent results with minimal side effects, while persistent or severe symptoms may indicate a need for dose adjustment