For most patients in our clinics, the honest answer is neither, yet
A provider should review injury history, training load, sleep quality, inflammation, lab results, and goals before recommending one option
These include: Tesamorelin: 1mg (Daily, fasted, usually before bed or pre-cardio) Ipamorelin: 500mcg (Stacked with Tesa) Retatrutide: 2mg-4mg (Weekly) The Super Stack to burn fat and quiet food noise: Retatrutide 2mg4mg (Weekly) Tirzepatide 2.5mg5mg (Weekly) Timing: Dosed 34 days apart (ie Reta on Sunday, Tirz on Wednesday) to maintain constant coverage Note that these peptides are not for human use and this info is from common user anecdotes
consistency with diet and exercise is key Wegovy: Rapid initial weight loss is common, though some experience gastrointestinal side effects during dose escalation Comparing Other Popular Weight Loss Medications GLP-1 receptor agonists consistently outperform oral medications in clinical weight loss outcomes
By day seven, fifty percent has been metabolized by your liver and kidneys, yet the remaining half still exerts meaningful biological effects on your appetite center and insulin secretion
Furthermore, exendin-4 can stimulate the cyclic adenosine monophosphate/protein kinase A (cAMP-PKA) pathway by activating GLP-1R, which then increases the level of non-phosphorylated -catenin to stimulate the Wnt/-catenin/NeuroD1 pathway and inhibits the activity of GSK-3, ultimately decreasing the hyperphosphorylation of AD-associated tau proteins regulated by GSK-3 (Kang et al., 2023)
