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Mutations in mTORC1 containing RAPTOR F1296E/M1297E alone, mTOR K471D/R472D/K474D alone or the combination of both reduced mTORC1 kinase activity (Fig

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Significant upregulation of markers such as DES and vimentin (VIM) indicates an expansion of mesenchymal cell populations, including hepatic stellate-like cells or fibroblasts (Fig

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There is no published stability data for the two held together in solution over time