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In tests on animal models, wounds showed faster contraction, better epithelialisation, more granulation tissue, and higher antioxidant enzyme activity [5,6]

They usually appear as dark brown-to-black papules, which are elevated, solid lesions or growths

& Rosell, R

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When these receptors are stimulated, they activate pathways involved in cell growth, repair, and defense against damage

Retinoic acid (RA) or tretinoin, in concentrations of 1%, 3%, and 5% in ethanol/propylene glycol, was first reported in 2001 as an agent for serial superficial peelings and indicated for melasma and photoaging [103, 104]